Changes occurring in Health care delivery and Medicine are the result of social, economical, technological, scientific forces that have evolved in the 21st century. Among the most significant changes are shift in disease patterns, advanced technology, increased consumer expectations and high costs of health care. These factors have redefined medical practices to fit into the changing health delivery system. Thus, Nursing Profession is ‘accountable’ to the society. i. e.
obliged to the laws regulating the professional activity. This ‘accountability’ is usually spelt out in “Patient Care Documents” established by hospital associations and medical associations or councils of every country (Ann J. Zwemer, 1995). In addition, nursing profession has defined its standards of accountability through a formal code of ethics. Schizophrenia is a mental disorder with impairment in perception and expression of reality characterized by delusions and hallucinations.
Clozapine is an atypical antipsychotic drug widely used in refractory Schizophrenia. There seems to be a cultural and geographical variations in dose response relationship and tolerability to the drug making the dose response unpredictable. The effective and tolerable range is between 100 mg to 900 mg, which makes it difficult to make a predictive, significant and valid correlation. There has been no positive correlation with serum level too.
Thus, there is a need to search for a clinically viable and simple method for growth response monitoring of the drug and treatment of schizophrenia. Thus, there is need for evidence based medical practice in the treatment and care of schizophrenia that works by providing a safe framework in which medical professionals and patients can make tough decisions by safe guarding their concerns by a fair and scientifically sound process together.