Acetylsalicylic acid is an acetyl derivative of salicylic acid which appears as a white and crystalline and a weakly acidic substance with a melting point of 135°C and is also known to be aspirin. It is one of the most widely used drugs that can lower fever and is used as a painkiller. According to (Escobel, 2011), Aspirin is synthesized through the reaction of salicylic acid with acetyl anhydride that causes a chemical reaction that turns salicylic acid’s hydroxyl group into an acetyl group, (R—OH > R—OCOCH3).
An inorganic acid such as phosphoric acid is used as a catalyst. Set-ups Figure 1. 1. Steam bath Figure 1. 2. Cold bath Figure 1. 3. Suction filtration set-up Figure 1. 4. Melting point apparatus List of Necessary Chemicals Name and Structure of the Compound Function in the Exercise Physical Properties Hazards Precautions Salicylic acid C7H6O3 Ultrasal-ER is flammable. Keep away from fire or flame. Keep bottle tightly capped when not in use. Ultrasal-ER is for external use only. Do not permit Ultrasal-ER to contact eyes or mucous membranes.
If contact with eyes or mucous membranes occurs, immediately flush with water for 15 minutes. Ultrasal-ER should not be allowed to contact normal skin surrounding the wart site, since localized irritation may occur. Treatment should be discontinued if excessive irritation occurs. Acetic anhydride 85% Phosphoric acid 95% Ethanol Commercial Aspirin II. DATA Table 1. Observation of chemical compounds used in the preparation of Acetylsalicylic acid (Aspirin) NAME OF THE COMPOUND DESCRIPTION Table 2. Observation on the crystallization of crude sample SAMPLE OBSERVATIONS.
Mixture of crude sample and solvent Mixture on steam bath Mixture on a ice bath Suction filtration a. filtrate b. residue Air dried crystals Table 3. Determination of percent yield of aspirin weight of sample + container __________g weight of container __________g weight of sample __________g % yield of aspirin __________g Table 4. Melting point data on crude sample Parameter Crude Sample Purified Sample Temp. when melting starts (°C) Temp. when melting complete (°C) Melting point range Melting point of pure sample (literature value): __________________________.
Table 5. Observation on recrystallization of crude sample SAMPLE OBSERVATIONS Cool bath a. filtrate b. residue Table 6. Recovery data on recrystallization of aspirin Parameter Crude Sample Recrystallized Sample Weight of container + sample (g) Weight of container (g) Weight of sample (g) (A) (B) Table 7. Observation between synthesized acetylsalicylic acid from commericially available aspirin TWO ASPIRINS OBSERVATIONS Synthesized acetylsalicylic acid Commercially available aspirin III. SAMPLE CALCULATIONS.