Drug dosage (adult): It is recommended to start the treatment with 0. 25% solution, 1 drop twice daily in the conjunctive sack. If the effect is inadequate, use 0. 5% solution, 1 drop twice daily in the affected eye. The maintenance therapy may continue with single application of 1 drop. Intraocular pressure should be monitored regularly 3-4 weeks after beginning of therapy and then periodically. Indications for use (with emphasis on surgery): For reduction of intraocular pressure and increased intraocular pressure, chronic glaucoma with opened angle of the anterior chamber of the eye, some cases of secondary glaucoma.
Administration route or routes: orally and ophthalmic routes. Two side effects: 1. Swelling or redness of your eyelids 2. Eye redness, discomfort, or sensitivity to light, drainage, crusting, or oozing of your eyes or eyelids An adverse effect: Usually the product is tolerated well. It has observed: conjunctivitis, blepharitis, keratitis, impaired corneal sensitivity; changes in refraction; diplopia; ptosis; reduction of lacrimal secretion. What precautions are given: This medication should not be used if you have certain medical conditions.
Before using this medicine, consult your doctor or pharmacist if you have: lung disease (e. g. , current or past history of asthma, severe chronic obstructive pulmonary disease), certain types of irregular heartbeats (sinus bradycardia, second or third degree AV block), certain types of heart disease (e. g. , severe heart failure, cardiogenic shock). Drug interactions: The simultaneous application of Timolol with calcium antagonists, catecholaminedepletion products and peroral beta-blockers may result in arterial hypotension or bradycardia.
Mydriasis may result from the combined application with adrenalincontaining drops. Contraindications: Hypersensitivity to the product; bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia; second or third degree of AV-block, manifested heart failure. The drug’s action on two different body systems: The Central Nervous System and the Cardiac Output and yes it does depress respirations because it’s parasympathetic which controls our heart rate and asthma.
How the drug absorbed is: Through the blood to the plasma proteins and distributed throughout the body. How is distributed: By binding of timolol to plasma proteins is minimal. The drug is relatively lipophilic, but less than propranolol, and is distributed into breast milk. How is the drug excreted: Through the kidneys and of your urine. Works Cited Bulgarian Pharmaceutical Group Ltd. (2013). Timolol. Retrieved from sopharma: http://www. sopharma. com/timolol. php (2000-2013). Retrieved from Drugs. com : http://www. drugs. com/mtm/timoptic-ocudose. html.