Ankylosing spondylitis Ankylosing spondylitis has no known specific cause, though genetic factors seem to be involved. In particular, people who have a gene called HLA-B27 are at significantly increased risk of developing ankylosing spondylitis. Although other joints can be involved, ankylosing spondylitis (AS) primarily affects the spine. In this particular type of arthritis, the joints and ligaments of the spine become inflamed. Antiphospholipid syndrome or antiphospholipi d antibody syndrome (APS or APLS) Antiphospholipid syndrome can cause arterial or venous blood clots, in any organ system, or pregnancy-related complications. •Thrombocytopenia •Recurrent fetal loss.
•Blood clotting •Venous thrombosis •Arterial occlusions •Leg ulcers •Hemolytic anemia •Premature birth •Deep vein thrombosis •Stroke •Pulmonary embolism •Heart attack Autoimmune Hemolytic Anemia (AIHA) The causes of AIHA are poorly understood. The disease may be primary, or secondary to another underlying illness. The most common causes of secondary warm-type AIHA include lymphoproliferative disorders (e. g. ,chronic lymphocytic leukemia, lymphoma) and other autoimmune disorders (e. g. , systemic lupus erythematosus, rheumatoid arthritis, scleroderma, ulcerativ e colitis).
The effects are usually related to the lack of oxygen and manifest themselves in the form of weakness, lethargy, and an increase in the heart and respiration rate. Vomiting or abdominal pain may be present. Gelacio, Seigfred Paul V. 14-UC-1882 UC-38 Dr. Alma Nacua Immunodeficiency Disease Causes Effects Agammaglobulinemia Agammaglobulinemia is a rare disorder that mainly affects males. It is caused by a gene defect that blocks the growth of normal, mature immune cells called B lymphocytes. Agammaglobulinemia is inherited, which means other people in your family may have the condition.
Effects of agammaglobulinemia include frequent infections like bronchitis, skin infections, sinusitis and respiratory infections. Agammaglobulinemia also can lead to chronic diarrhea and conjuctivitis (eye infection). Severe Combined Immunodeficiency Caused by defects in any of several possible genes, SCID makes those affected highly susceptible to life-threatening infections by viruses, bacteria and fungi. Effects of SCID in infants include poor growth, rashes that look like eczema, chronic diarrhea and recurrent thrush in the mouth.
Chronic Granulomatous Disease Chronic granulomatous disease (CGD) is a genetic disorder in which certain immune system cells are unable to kill some types of bacteria and fungi. The disorder leads to long term (chronic) and repeated (recurrent) infections. The condition is often discovered in very early childhood. Milder forms may be diagnosed during the teen years or even in adulthood. Effects of this disease include pneumonia, infected dermatitis (skin disorder), lymphadenitis (inflammation of the lymph nodes) and a large spleen (splenomegaly). The liver can also enlarge (hepatomegaly) and a bone infection (osteomyelitis) can also develop.